01:694:407 Study Guide - Midterm Guide: Gluconeogenesis, Glycogen, Allosteric Regulation

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Atkinson"s energy charge function -- energetic phosphate level in the cell. = (atp + . 5adp) / (atp + adp + amp) Nearly every pathway is regulated by atp, adp and amp in some way. Atp concentration is very important if it is too low, rates that depend on it decrease significantly. Changes in atp / adp ratio affect reactions. Amp tells even more though about metabolic regulation because it is usually in such low concentrations. Ampk -- amp active protein kinase phosphorylates particular proteins to regulate their activity when the levels of amp are high. An result of this includes the mobilization of glucose and fa oxidation to utilize in active state. camp dependent protein kinase = pka, which is usually part of cascade mechanism. 15. 3 -- coordinated regulation of glycolysis and gluconeogenesis. Remember that glycolysis and gluconeogenesis have different products in mind (glycolysis -- break down glucose; gluconeogenesis -- create glucose).

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