PHR 4111- Midterm Exam Guide - Comprehensive Notes for the exam ( 38 pages long!)
16 Feb 2018
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K+ blockers; no e ect on conduction velocity or automaticity. Wolf-parkinson white syndrome; a. b; ventricular tachycardia; a/v arrhythmias. Dea by n-deethylation via 3a4/1a1. inhibits drug clearance of those undergoing oxidation. Amiodarone analog lacking iodine; propyl chain with n-butyl on n. 3a4 to active and inactive metabolites; substrate of 3a4. Symmetrical analog of ibutilide with additional phenylmethanesufonamide w/o. Analog of stall w/ ethylene between ophenethyl and n groups made by butyl homolog. Excreted changed in urine and feces; 8 metabolites; omega oxidation of end ch3 to acid followed by beta oxidation of the heptyl side chain. Drugs that prolong qt interval (ndhp, hctz, quinolones, tca); hypomagnesia; hypokalemia. 3a4 (keto/itra/voriconazole, cyclosporine, telith/clarythromycin,ritonavir) 3a4 inducers (rifampin, phenobarbital; phenytoin, carb, st. john"s wort) permanent hf; lv dysfunction; class 3/4. Bradycardia; hypomagnesia, hypokalemia; qt prolongation; nvd, increased scr; rash; hepatotox w/i 1st. Ddi use with (-) chronotropes (bb, dig, ndhp, clonidine) increase risk of bradycardia; increased lvl of digoxin,
