BIOL 4376 Study Guide - Final Guide: Coronary Artery Disease, Statin, Familial Hypercholesterolemia

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29 Jul 2020
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Roles include: cell membrane formation and hormone synthesis. Lipoproteins: transport lipids around body; particles with surfaces that consist of phospholipid, free cholesterol, protein and cores of triglyceride and cholesterol esters. Consists of: total cholesterol, ldl, hdl, triglycerides. High total cholesterol, high ldl cholesterol, high triglycerides, or low hdl cholesterol. Increases risk of coronary heart disease, mi, and stroke. Procedure: patient must fast for at least 9-12 hours prior (non-fasting can falsely elevate triglyceride levels) Important component of cell membranes; necessary for synthesis of hormones and bile acids. Diets high in cholesterol and saturated fat. Common drug-induced causes: atypical antipsychotics (olanzapine, risperidone), thiazide diuretics (hctz) Major cholesterol transport protein which comprises 60-70% of total serum cholesterol. Considered bad cholesterol; major target of hmg co-a reductase inhibitor (statin) therapy. Causes of high ldl: same causes as high total cholesterol. Responsible for transport of 20-30% of serum cholesterol. Removes excess cholesterol from peripheral tissues to the liver.

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