BIOL 4376 Final: Pharmc exam 1

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Published on 29 Jul 2020
School
Temple University
Department
Biology
Course
BIOL 4376
121.Adherents leads to?
Phagocytosis and dissociation.
122. To extend the action of insulin, besides the previously mentioned pH based approach
(lantus insulin) another way is to
form poorly soluble crystals with zinc (lente, Humulin-L, Novolin-L)
123. Relationships
size-The larger the crystal the the slower absorption.
Polymorphism- the higher the melting points the slower the absorption.
Amorphous absorbed more quickly than Crystalline
124. Lente insulin should look uniformly cloudy because of the presence of?
zinc-insulin crystals
125. Manufacturing processes-
depyrogenation, sterilization, aseptic filling, lyophilization.
126. Why are pyrogens difficult to remove?
Because they are resistant to moderate heating/steam sterilization
127.steriliaztion techniques?
Dry heat, steam sterilization, filtration, irradiation, chemical sterilization
128.Filtration: how large of a micron filter is used in a IV set to remove particulates which may
block pulmonary circulation.
5 microns and 20 nm to remove virus
129.Filtration method dis/advantages?
Advantages- removes particulates, cool process, good for thermally unstable
compounds, can be a continuous process.
Disadvantages- must be liquid, does not depyrogenate, must be aseptic after filtration,
drug may bind to filter.
130.When should you use aseptic fill
whenever terminal sterilization is not possible or preferred.
131.true or false filtration must be combined with aseptic filling?
True
132. Considerations of aseptic processing
Surface, air, cip
133.Laminar flow station: if you are dealing with chemotherapy drugs which would you prefer
horizontal or vertical?
Vertical
134. method of cleaning the interior surfaces of process and associated fittings, without
disassembly.
CIP
135. CIP pros and cons
pros-self-contained , sterility assured and removes human error.
Cons- hard to set up.
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136.Dehydartion to produce an amorphous solid that is more convenient to handle and may be
stored for a longer period of time. Performed by freezing the liquid, lowering the pressure and
removing water by sublimation.
Lyophilization
137. Lyophilization pros and cons
pros- cold process, preserves drugs in dry state, can preserve drug in amorphous state.
Cons- expensive, low throughput, must design formulation as a liquid and stabilize as a solid,
drug may revert from amorphous state to crystalline state.
138.Drug X
amorphous melting range
60 to 80
solubility 10 mcg/ml in water
bioavailability in 60%
crystalline
melting point 147 to 149
solubility< 1mcg/ml in water
bioavailability
10%
Emulsions based dosage forms and semi-solid dosage forms ppt 2
1.Disperse system-
Consists of 2 or more physically immiscible phases, in which the dispersed phase is
uniformly distributed, in discrete units, within the dispersing phase.
2.Example of a dispersed system?
Oil droplets dispersed in water
3. Dispersed systems classified in which two ways
Size and Interaction
4. Size classifications?
Molecular dispersions (<1nm eg. protein), colloidal (1 to .5 um whip cream, mayo),
Coarse (>.5um many emulsions/suspensions)
5. Interaction Classification?
Lyophilic (solvent loving) ex gelatin
Lyophobic (solvent hating) eg colloidal charcoal.
Emulsion (liquid and semi-solid)-types
6.oil in water (o/w)
some lotions and most creams
7. Water in oil (w/o)
cold cream, hydrophilic ointments
8.multiple emulsions
Water in oil water (w/o/w) oil in water-oil (o/w/o)
9. Microemulsions
5-140nm
more uniform in size
10. emulsion types
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Document Summary

Polymorphism- the higher the melting points the slower the absorption. Amorphous absorbed more quickly than crystalline zinc-insulin crystals. 5 microns and 20 nm to remove virus depyrogenation, sterilization, aseptic filling, lyophilization. Because they are resistant to moderate heating/steam sterilization. Dry heat, steam sterilization, filtration, irradiation, chemical sterilization. Advantages- removes particulates, cool process, good for thermally unstable. 128. filtration: how large of a micron filter is used in a iv set to remove particulates which may block pulmonary circulation. 129. filtration method dis/advantages? compounds, can be a continuous process. drug may bind to filter. 131. true or false filtration must be combined with aseptic filling: considerations of aseptic processing. Cons- hard to set up. whenever terminal sterilization is not possible or preferred. 136. dehydartion to produce an amorphous solid that is more convenient to handle and may be stored for a longer period of time.