BIOL 4376 Final: review

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Published on 29 Jul 2020
School
Temple University
Department
Biology
Course
BIOL 4376
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PARENTERAL DOSAGE FORMS Chapter Review tnt presen
nee presence
acronyms
hiangYfirfaes
Parenteral injectable bypass an cinieslines ME pp
why Parenteral quickaction RBioavailability Aer predictibleabsorption
1M canlastfor months controlleddrugeffect cont supply possible on
ROAcutaneous intracutaneous intradermal
SQISChhypodermicing
IM
IP Cintraperitoneal
Etc intra
arterial foranestheticsintra
articularjoints intratumoralchemo
drug
intrathecalspinal cord intracardiac
Irrigationfor wound dialysis
IV BolusCiv
push fastest
infusion largeaunt long
time slow
short
infusion inwww.r.ttime
Tko
camp
open w
drip
Hyperalimentation excessivenutrition
GTPNtotalparenteral
Nutrition Fluid thruvein
nutrition
infusion Rate mL time knowconhowf.to
yrsfreeze
dry
cpowder
Dosage Forms my1time
singleDose multipledosevialsAmpouleSyringe pre
filledsyringe Bags bottlesmini
bagsiphiiedprodyd
ae.sn
Product Requirements
reqmore
specific vs Oral
Parenteral isotonic preferred
qsterility Particulate4Pyrogen
freeonly
tensurfactants approvedTween20 Tween
80
Sterility
mum
absolutely freeof viable microbes indie noninfective ones
use
stun
method TrLmiUiizdinC fjnalstage7vsAEqeCduring.t.GGEfjYdeanenvt
heat
final
product
sterility Disi notcomplete elimination
reduce pathogenic microbes
Impt bc Prevent infections givenlesser barriers tnt wparenterals noskin1
intestine to protect
Prevent
Biological Degradation ofdrugs
bymicrobes
waterdextrosefuel bacterialfungalgrowth
ms
sample innoculate
media incubate observe
for
sterilityTests USP Ct caddsubst at
favor in
days growth
bacterialgrowth 320
sterility if ab ab
senseofgrowth
PIXIE fever
inducing hypersensisitivitytriggering agents greydompoofenff
endogenous cytokines vs exogenous endotoxin
PyrogenTesting USP4517 Rest InjectRabbit wsolution monitor
Qt for
112
hr bodytemp Tz0.5 C
pyrogen tree congratulations
Bacteria
endotoxin
test
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Document Summary

Parenteral dosage forms chapter review acronyms tnt presen nee presence p p hiangyfirfaes predictibleabsorption. Parenteral injectable bypass an cinieslines why parenteral quick action r bioavailability aer. Iv boluscivpush fastest intrathecalspinal cord intracardiac slow infusion largeaunt longtime inwww. r. ttime shortinfusion. Gtpntotalparenteralnutrition fluid thruvein nutrition infusion rate ml time my1time knowconhowf. to freezedrycpowder yrs. Dosage forms single dose multipledosevialsampoulesyringe prefilled syringe bags bottlesminibagsi phiiedprodydae. sn. Sterilitymum absolutely freeof viable microbes indie noninfective ones usestun method trlmiuiizdinc fjnalstage7vsaeqecduring. t. ggefjydeanenvt sterility notcomplete elimination heatfinalproduct. Impt bc prevent infections givenlesser barriers tnt w parenterals noskin1intestine to protect reduce. 320 sterilitytests usp ct observefor growth sterility if ab absenseofgrowth grey dompoofenff. Pixie feverinducing hypersensisitivitytriggering agents endogenous cytokines vs exogenous endotoxin. Injectrabbit w solution monitor pyrogen tree congratulations bodytemp t z0. 5 c. 0 tonicity parenteraldrug y tbeisotonewithbodycuescrises sgaexnoseinioounscnae. udingsoueesioisoam. asaa asionic. ge inioomeg. sidamselssw. o. a. i. ws nss hypotonicsocacrbcsweep g o. us nssieo. agnaaao. mn. Ihypertonicsoicrbcsnrinksseg. sins. osow. rssns0 mixingisotonicsots resultinisotonicsodag comedsw toomins isaswans itparenteralarenotisotonictheyarew aindd d. ze. ge hypotonicdrugs dangerousforn exceptionsmypoenegivenin timeyougiveo. usi. nsoro. zsi. nscn. conotgivendirectlyopreventhemolysis. Lal assay i r py g intensityindicatesendotoxinlevels duetocrabbodyfluidreactingwendoxins us turbidity 1coagulation.