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KINS 1224 Study Guide - Midterm Guide: Eosinophil, Memory B Cell, Immunoglobulin Light Chain

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mauvehamster904
21 Mar 2016
School
Temple University
Department
Kinesiology
Course
KINS 1224
Professor
rooney

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Document Summary

Explain how b cells recognize and respond to an antigen: An immunocompetent b cell has thousands of surface receptors for one antigen. Antigens bind to one of these receptors and is taken in in by cell receptor mediated endocytosis. The b cell will digest the antigen and display some of the epitopes to its mhc-ii proteins: describe the structure, types, and actions of antibodies: Immunoglobulins are antibodies that are defense gamma globulins found in the blood plasma, tissue fluids, body secretions, and some leukocyte membranes. Antibody monomer- the basic structural unit of an antibody composed of 4 polypeptides. Consists of the two heavy chains 400 aa long and 2 light chains which are 200 aa long. Each 4 chain have a variable v region that gives an antibody its uniqueness. The v regions of a heavy chain and light chain combine to form an antigen- binding site on each arm.

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Related Questions

True / False Questions

01. _____ Antibody is composed of 2identical long heavy chains and 2 identical shorter lightchains.

02. _____ Variable (V) and constant(C) regions are part of both heavy and light chains.

03. _____ Variable regions for heavyand light chains from the same antibody molecule are alwaysidentical.

04. _____ Variable region of lightchains are encoded by the DNA sequences that contain rearranged V,D, and J segments.

05. _____ Fc part of the antibody isnot important, F(ab’)2 fragment has the same binding andeffector capacity.

06. _____ Fab fragments are generatedby alternative splicing.

07. _____ J chain is used as asurrogate light chain during pre-B cell receptor testing forsuccessful V(D)J rearrangement.

08. _____ Binding of the antigen byantibody is stabilized by disulfide bonds.

09. _____ RAG1/2 are always expressedin B cells at high level, because B cells need RAG1/2 to constantlyrearrange their V regions.

10. _____ “N” (non template)nucleotides are added by TdT.

11. _____ The 12/23 rule is appliedduring class switching.

12. _____ For B cells, V(D)Jrecombination occurs only in the bone marrow.

13. _____ The process of somatichypermutation helps to improve specificity of the antibody.

14. _____ In late pro-B cells, Vsegment is rearranged with DJ segments.

15. _____ Failure to eliminateself-reactive B cells may lead to serious autoimmune diseases.

16. _____ Mature, naïve B cellsexpress IgD and any of the other classes of antibody (IgM, IgG,IgA, or IgE) on their surfaces.

17. _____ B1 cells are present in theperitoneal cavity, pleural spaces and brain.

18. _____ AID (activation inducedcytidine deaminase) is expressed only in B cells and it canintroduce breaks in double stranded DNA.

19. _____ Different classes (isotypes)of antibodies have different effector functions, which aretriggered by special receptors expressed by a variety of cells.

20. _____ Plasma cells are terminallydifferentiated cells that produce large quantities ofantibodies.

21. _____ Repeated exposure to thesame antigen eventually leads to immunological exhaustion and lackof immunity, because there is no room for new plasma cells in thebone marrow.

22. _____ Germinal centers arespecialized sites within the bone marrow where Ig genes ofactivated B cells undergo affinity maturation.

23. _____ B cells can present antigensto T helper cells.

24. _____ Co-stimulatory molecules arerequired for efficient generation of memory B cells.

25. _____ Lymphocytes migrate to thelymphoid tissues in response to chemokines.

26. _____ Class switching duringgerminal center reaction is a random process.

27. _____ T cell independent responsescan generate strong and long lasting B cell memory.

28. _____ Fc receptors that arepresent on many different cell types are crucial for removal of thepathogens.

29. _____ The ideal vaccine should bedesigned to mimic the natural course of infection without causingsymptoms of the disease.

30. _____ The protective immunity canbe generated against any pathogen because there is virtuallyunlimited number of possible V regions, thus any antigen can berecognize by an antibody.

Please briefly explain reasoning for all questions.

1)

Which of the following is a component of a vertebrate kidney? (Select all correct choices.)
glomerulus
Bowman's capsule
renal tubules
collecting ducts
Malphigian tubules

2)

In organisms, the ability to control osmosis depends on the properties of the plasma membranes of individual cells. Based on their ability to permit the free movement of water and some solutes, these membranes are best described as: (select all correct choices)
impermeable.
permeable.
semipermeable.
diffusible.
impervious.

3)

True or false: The inner cell mass of the blastocyst becomes the embryo, while the outer cell layer of the blastocyst forms part of the placenta.
true
false

4)

Which of the following accurately characterizes the early cleavage divisions in most animals, although not necessarily in mammals?
They do not involve an increase in the size of the zygote.
They are directed by the zygote’s genome.
They are relatively slow.
They do not occur at the same time, so at any given moment the zygote may have an odd number of cells.
All of these choices are correct.

5)

A key difference between hormonal regulation of the reproductive systems of males and females is that:
LH and FSH are released only in females.
LH and FSH are released only in males.
LH and FSH are released cyclically in females but nearly continuously in males.
LH is released in males and FSH is released in females.
LH is released continuously in males and FSH is released cyclically in females.

6)

Compared to sexual reproduction, asexual reproduction: (select all correct choices)
requires less investment in attracting mates.
allows much more rapid population growth.
is rarely found as the sole mechanism of reproduction.
results in the production of genetically identical cells or individuals.
involves meiosis and fertilization as core processes.

7)

True or false: In response to LH and FSH, ovaries secrete estrogen and progesterone.
true
false

8)

During the luteal phase of the menstrual cycle, if the oocyte is not fertilized, a number of events occur which are listed below. Select the answer that places the events in the correct chronological order.

Events:
1. the lining of the uterus is shed
2. the corpus luteum secretes progesterone
3. follicle cells are converted to the corpus luteum
4. the corpus luteum degenerates
5. estrogen and progesterone levels fall

3, 2, 4, 5, 1

1, 2, 3, 4, 5

2, 4, 3, 1, 5

4, 3, 2, 1, 5
5, 2, 3, 4, 1

9)

If an antibody is missing its Fc fragment, what would happen if this antibody encounters its target antigen in the bloodstream? Select all correct choices.
The antibody would be able to bind the antigen at a specific epitope.
The antibody would be able to bind the antigen, but not at an epitope site.
The antibody would not be able to bind to the antigen.
The antibody would be able to activate components of the complement system.
The antibody would not be able to activate components of the complement system.

10)

If an individual carries a mutation that results in a complete lack of MHC class I proteins, how would the individual’s immune response be affected? Select all correct choices.
Memory cell antibodies would not be able to attach to antigen epitopes.
Cytotoxic T cells would not be able to target (and destroy) infected cells.
Helper T cells would not be able to interact with antigen-presenting cells.
Plasma cell antibodies would not be able to attach to antigen epitopes.

11)

If an individual carries a mutation that results in a complete lack of MHC class I proteins, how would the individual’s immune response be affected? Select all correct choices.
Memory cell antibodies would not be able to attach to antigen epitopes.
Cytotoxic T cells would not be able to target (and destroy) infected cells.
Helper T cells would not be able to interact with antigen-presenting cells.
Plasma cell antibodies would not be able to attach to antigen epitopes.

12)

Which of the following statements is true regarding T cell receptors? Select all correct choices.
They recognize antigen-MHC complexes.
They contain variable and constant regions.
They are composed of two heavy (H) chains and two light (L) chains.
They are formed by the rearrangement of V, J, C, and D gene segments.
They can be found in the bloodstream independent of T cells.
1) Which of the following is a component of a vertebrate kidney? (Select all correct choices.)
glomerulus
Bowman's capsule
renal tubules
collecting ducts
Malphigian tubules

2)

In organisms, the ability to control osmosis depends on the properties of the plasma membranes of individual cells. Based on their ability to permit the free movement of water and some solutes, these membranes are best described as: (select all correct choices)
impermeable.
permeable.
semipermeable.
diffusible.
impervious.

3)I selected cortex; inner medulla, it was wrong.

The loops of Henle create a concentration gradient in the interstitial fluid surrounding the loop, with the concentration highest in the ____________ and lowest in the ____________ of the kidney.
inner medulla; cortex
outer medulla; inner medulla
outer medulla; cortex
cortex; inner medulla
cortex; outer medulla

4)

The main solutes in the filtrate as it enters the distal convoluted tubule are: (select all correct choices)
urea.
electrolytes.
other wastes.
amino acids.
nucleotides.

5) Ensure all correct choices are selected, for this question I only selected osmosis and it was wrong,

Water moves by: (select all correct choices)
random molecular motion.
active transport.
passive transport.
osmosis.
facilitated diffusion

6)

Compared to sexual reproduction, asexual reproduction: (select all correct choices)
requires less investment in attracting mates.
allows much more rapid population growth.
is rarely found as the sole mechanism of reproduction.
results in the production of genetically identical cells or individuals.
involves meiosis and fertilization as core processes.

7)

A key difference between hormonal regulation of the reproductive systems of males and females is that:
LH and FSH are released only in females.
LH and FSH are released only in males.
LH and FSH are released cyclically in females but nearly continuously in males.
LH is released in males and FSH is released in females.
LH is released continuously in males and FSH is released cyclically in females.

8)

True or false: In response to LH and FSH, ovaries secrete estrogen and progesterone.
true
false

9)

During the luteal phase of the menstrual cycle, if the oocyte is not fertilized, a number of events occur which are listed below. Select the answer that places the events in the correct chronological order.

Events:
1. the lining of the uterus is shed
2. the corpus luteum secretes progesterone
3. follicle cells are converted to the corpus luteum
4. the corpus luteum degenerates
5. estrogen and progesterone levels fall
3, 2, 4, 5, 1
1, 2, 3, 4, 5
2, 4, 3, 1, 5
4, 3, 2, 1, 5
5, 2, 3, 4, 1

10)

If an antibody is missing its Fc fragment, what would happen if this antibody encounters its target antigen in the bloodstream? Select all correct choices.
The antibody would be able to bind the antigen at a specific epitope.
The antibody would be able to bind the antigen, but not at an epitope site.
The antibody would not be able to bind to the antigen.
The antibody would be able to activate components of the complement system.
The antibody would not be able to activate components of the complement system.

11)

If an individual carries a mutation that results in a complete lack of MHC class I proteins, how would the individual’s immune response be affected? Select all correct choices.
Memory cell antibodies would not be able to attach to antigen epitopes.
Cytotoxic T cells would not be able to target (and destroy) infected cells.
Helper T cells would not be able to interact with antigen-presenting cells.
Plasma cell antibodies would not be able to attach to antigen epitopes.

12)

Which of the following statements is true regarding T cell receptors? Select all correct choices.
They recognize antigen-MHC complexes.
They contain variable and constant regions.
They are composed of two heavy (H) chains and two light (L) chains.
They are formed by the rearrangement of V, J, C, and D gene segments.
They can be found in the bloodstream independent of T cells.