BSC 431 Study Guide - Midterm Guide: Streptomycin, Mycoplasma, Phospholipase C

• School: University of Alabama
• Department: Biological Sciences
• Course: BSC 431
• Professor: Julie Olson

Document Summary

Facultative anaerobe, catalase positive, gram positive rod, nonmotile. Begins as an upper respiratory tract illness (sore throat, fever) Can be cutaneous (chronic, non-healing ulcer w/ gray membrane) Release of 3-component exotoxin may result in systemic disease. Toxin binds to receptor on cell surface, enters by endosome, ph drop, insertion into endosomal membrane. Elek immundiffusion test can determine presence (ab:ag complex precipitates in x) Iron can inhibit production of toxin via the tox gene. Immunization (toxoid) given in 2-3 doses at 2,4, & 6 months. Ocular infections may occur after penetrating eye injuries. Characteristic square ends; spores not seen in clinical specimens. Transmission usually from contact w/ infected animals (no person to person) Gastrointestinal infection- follows consumption of poorly cooked, contaminated meat. Bacteria enter through break in intestinal mucosa (spread to lymphatic system) Initial symptoms resemble the flu (fever, chest pains, cough, headache, chills)