MIC 301 Study Guide - Midterm Guide: Vancomycin, Bacitracin, Chloramphenicol

• School: University at Buffalo
• Department: Microbiology And Immunology
• Course: MIC 301
• Professor: kevinwise

Document Summary

Chapter 10: controlling microbial growth in the body antimicrobial drugs. First antimicrobial discovered, but not the fist in widespread use. Selectively toxic to certain fungal or bacterial cells with cell walls, not to animals without cell walls. Inhibit translation by targeting the differences between prokaryotic and eukaryotic ribosomes. Inhibit general metabolic pathways not sued by humans. Inhibition of pathogen"s attachment or recognition of host. Mechanism: prevent the cross-linkage of nam subunits, beta-lactams (not vancomycin) form rings, inhibit ptg formation by irreversibly bind to the enzymes that cross-link nam subunit. Like beta-lactams, vancomycin, cycloserine and bacitracin result in cell lysis due to the effects of osmotic pressure. Explain the mechanism of the antimicrobials ad what organisms they work on. Clavulanic acid could be used to protect penicillin formulation. Bacterial with cell walls (most g+ and some g-) Directly interfere with particular alanine-alanine bridges that link the. Blocks the transport of nag and nam from cytoplasm out to the wall.