PMY 302 Study Guide - Midterm Guide: Diazepam, Kainite, Zolpidem
17 May 2016
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5-ht 1a receptor agonists: buspirone, for chronic anxiety. Propranolol: for situational or performance anxiety: gaba, main inhibitory nt in cns, two types. G protein coupled receptor, linked to gi/o inhibit ac and. Ca2+ channels, activate k+ channels: gaba a receptor. 5 subunits, benzodiazepine doesn"t bind to same site as gaba. Benzodiazepines, barbiturates, ethanol modulate gaba a: bz, flumazenil (romazicon): competitive bz antagonist, general. Increase frequency of cl- channel opening in present of gaba. Shift gaba dose-response to the left, no increase in current evoked make the cell more sensitive to gaba: mechanism. Produce little sedation, depth of cns depression is limited. Anterograde amnesia (no memory during effect of bz) interfere with new memories formation, can recall past used in endoscopy (stressful events) Cause muscle relaxation only at dose causing sedation. Orally: no respiratory depression combined with ethanol: yes: uses. Novel bz are preferred alter sleep stages. Alcohol withdrawal: chlordiazepoxide and diazepam: adverse effect. Mild euphoric effect and reduced behavioral inhibition.
