PMY 302 Study Guide - Final Guide: Cortisone, Pituitary Gland, Dexamethasone

• School: University at Buffalo
• Department: Pharmacology and Toxicology
• Course: PMY 302
• Professor: stewart Clark

Document Summary

Adrenal steroids and related drugs: adrenal glands, adrenal medulla: produces the fight-or-flight hormones ep and ne, adrenal cortex: uses cholesterol as a starting material an synthesizes an secretes 3 kinds of steroid hormones (adrenocorticosteroids) Metabolic effects: raise blood glucose, aa, tg. Promote na+ reabsorption an k+ excretion in kidney. Mainly used as anti-inflammatory and immunosuppressive drugs in the treatment of allergic, inflammatory and autoimmune disorders. Replacement therapy in addison"s disease (fludrocortisone: usually classified by potency and duration of action. Long acting: betamethasone, dexamethasone: cortisone cortisol interconversion. Cortisol cortisone (kidney), through hsd2: disorders of the adrenal cortex, adrenal hormone excess. Elevated by 3 causes: acth excess by pituitary adenoma cushing syndrome, glucocorticoid excess by adrenal adenoma, high dose of glucocorticoids in the treatment of disease. Characteristics: weight gain (abdomen, face, neck& upper back), excess blood cortisol. Diagnosis: if given dexamethasone, acth is suppressed and blood cortisol is lower acth-dependent, pituitary adenoma, cushing syndrome, if cortisol does response adrenal adenoma.