2011 Exam 1.pdf

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Department
Biological Science
Course
BISC 336
Professor
Dr.Sarah Liljegren
Semester
Fall

Description
Name%____________________________________________%%%%%%%%%%%%%%%%%%%%%%% Genetics Exam #1: September 21, 2011 Clearly write your name on the exam and an answer for each question and turn it in with your completed scantron. You may use a calculator; no cell phones allowed. TRUE/FALSE. Write ‘A’ if the statement is true and ‘B’ if the statement is false. 1. Auxotrophs have lost, through mutation, the ability to grow on minimal media. 2. In plant cells, constriction of the plasma membrane during telophase produces a cell furrow. 3. Individuals with familial Down syndro me have a translocation of chromosomes 14 and 18. 4. Gene inversions provide an explanation for the origin of gene families. 5. A transgenic mouse can be patented. 6. All the daughters of a man with an X-linked recessive allele will inherit the associated trait. 7. An allele is a variant form of a gene. 8. The meiotic cell cycle includes one round of DNA replication and two cell divisons. 9. The genetic material DNA consists of basic subunits called amino acids. 10. About 10% of human genes undergo maternal or paternal imprinting. 11. Xist protein coats the X-chromosome that will form a Barr body, and initiates the dosage compensation process. 12. F+ and F- bacteria undergo conjugation as a means to transfer genetic information. Which of the following statements is correct? A. F- bacteria can form a conjugation tube. B. Hfr bacteria transfer the F plasmid through the conjugation tube. C. F- bacteria transfer the F plasmid through the conjugation tube. D. F- bacteria can undergo genetic recombination to replace genes on their chromosome. E. The F plasmid can integrate at only one location on a bacterial chromosome. A 0 13. Two indiviuals with I I genotypes and one wild-type copy each of the FUT1 gene have children. What is the probability that a child will have an A blood type phenotype? A. 25% B. 37.5% C. 56.25% D. 62.5% E. 75% 14. During meiosis, genetic recombination results from which of the following? A. Crossing over between sister chromatids of a pair of non -homologous chromosomes B. Crossing over between non -sister chromatids of a pair of homologous chromosomes C. Crossing over between sister chromatids of a pair of homologous chromosomes D. Crossing over between non -sister chromatids of a pair of non -homologous chromosomes 15. A chromosomal translocation will result from which of the following? A. Crossing over between sister chromatids of a pair of non -homologous chromosomes B. Crossing over between non -sister chromatids of a pair of homologous chromosomes C. Crossing over between sister chromatids of a pair of homologous chromosomes D. Crossing over between non -sister chromatids of a pair of non -homologous chromosomes Name%____________________________________________%%%%%%%%%%%%%%%%%%%%%%% 16. For the following pedigree, choose the mode of inheritance that is the best fit. A. Autosomal recessive B. Autosomal dominant C. X-linked recessive D. X-linked dominant E. Mitochondrial inheritance 17. For the following pedigree, choose the mode of inheritance that is the best fit. A. Autosomal recessive B. Autosomal dominant C. X-linked recessive D. X-linked dominant E. Mitochondrial inheritance 18. A man was recently diagnosed with Huntington’s disease. What is the probability that boof his daughters will inherit this disease? A. 0 B. 25% C. 50% D. 75% E. 100% 19. A woman has sickle cell anemia and her husband found out that he is a carrier of the mutant beta-globin allele. What is the probability that their son will inherit this dis order? A. 0 B. 25% C. 50% D. 75% E. 100% 20. Sperm produced from a first-division chromosomal non -disjunction during meiosis could cause which of the following disorders: A. Klinefelter’s syndrome B. XY females C. Cri du chat syndrome D. Philadelphia chromosome 21. Recessive mutations in either of two genes, eyeless (ey) or eyes absent (eya), are known to cause flies without eyes. In a genetic screen, you find a fly without eyes and wonder if you’ve found a new eye mutant. If a test cross of your unknown fly to the eya homozygous mutant results in wild -type flies in the F1 generation, what can you conclude? A. Mutations in the ey gene cause the mutant phenotype of your unknown fly. B. Mutations in the ey gene do not cause the mutant phenotype of your unknown fly. C. Mutations in the eya gene cause the mutant phenotype of your unknown fly. D. Mutations in the eya gene do not cause the mutant phenotype of your unknown fly. E. Mutations in a new gene cause the mutant phenotype of your unknown fly. Name%____________________________________________%%%%%%%%%%%%%%%%%%%%%%% 22-26. In a mapping cross of a female fly heterozygous for three linked, recessive genes, the foll owing phenotypes of F1 progeny were obtained. a+ b c 421 a b+ c+ 424 a+ b+ c 34 a b c+ 28 a b+ c 46 a+ b c+ 42 a b c 2 a+ b+ c+ 3 22. What were the linked allele combinations on the P1 heterozygous female’s chromosomes? A. a+ b+ c+ / a b c B. a b+ c / a+ b c+ C. a+ b+ c / a b c+ D. a+ b c / a b+ c+ E. None of the above 23. Based on the F1 mapping data above, what is the gene order of the linked genes? A. a b c B. b a c C. b c a 24. What is the order of the linked alleles on the P1 heterozygous female’s chromosomes? A. a+ b c / a b+ c+ B. b a+ c / b+ a c+ C. b c a+ / b+ c+ a 25. What would be the single cross over allele combinations between a and b? A. a+ b+ c+/ a b c B. b a c+ / b+ a+ c C. genes a and b are not adjacent to each other 26. What is t
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