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Final

BIO SCI 98 Study Guide - Final Guide: Triosephosphate Isomerase, Pyruvate Carboxylase, Phosphofructokinase 1Exam


Department
Biological Sciences
Course Code
BIO SCI 98
Professor
Tsai
Study Guide
Final

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Bio 98C Final Exam 3/22/18 Name SID
Either full names or abbreviations of enzymes/intermediates are fine.
A1). Name the reversible steps for the second phase of glycolysis. (3 pt)
_____________________________________ ___________________________________________
_________________________________________________
A2). Metabolism includes both catabolism and __________________________ (1 pt)
A3). How many molecules of ATP are needed to convert 2 pyruvates into 1 glucose during gluconeogenesis?
__________________________. During gluconeogenesis, oxaloacetate (OAA) is converted to ______________________
so that it can be transported from the matrix to cytoplasm. (2 pt)
A4). Answer “inhibit”, “activate” or “no change” for the following scenarios (3 pt total):
a) Lots of fructose-1,6-bisphosphate on the rate of phosphofructokinase 1 (PFK1)
b) Lots of AMP on the rate of triose phosphate isomerase (TPI)
c) Lots of acetyl-CoA on pyruvate carboxylase (PC)
(a)_____________________________ (b)_____________________________ (c) __________________________
A5). How many NET molecules of ATP will one molecule of glucose-1-phosphate (G1P) generate going through only
glycolysis and TCA? __________________________ (write the answer in the underline, 2 pt)
A6). Name the enzyme that produces NADH during glycolysis
_____________________________ (1 pt).
Draw the chemical structure of the substrate of this enzyme (2 pt).
A7). What is the purpose of fermentation? (Give only one short sentence)
____________________________________________________________________________________________ (2 pt)
Draw chemical structure here.
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Bio 98C Final Exam 3/22/18 Name SID
B1). Consider a liver cell stimulated with glucagon.
a) How does it affect the rate of lipase in these cells?
b) How does it affect the rate of pyruvate carboxylase (PC) in these cells?
c) What is its effect on the rate of glycogen phosphorylase?
d) What is its effect on the rate of protein synthesis?
e) What is its effect on fatty acyl-CoA synthetase?
(Answer a, b, c, d, e simply by saying decrease”, “no change” or “increase”, 5 pt total)
(a)_____________________________ (b)_____________________________
(c)_____________________________ (d)_____________________________ (e) ______________________________
B2). Pyruvate dehydrogenase (PDH). Mercury poisoned ________________________, a cofactor of PDH (1 pt).
B3). The product from E3 of PDH is _________________________________________. (1 pt)
B4) Babies who suffer from the “polygamists’ Down syndrome” has a mutation in the TCA enzyme called
_____________________________ (1 pt).
B5). Give the name of the TCA enzyme that catalyzes the oxidative decarboxylation of a six-carbon substrate
_______________________________ (1 pt).
10). Match the following enzymes with the appropriate statement. Use each answer once. (5 pt)
B5). Name three enzymes in the aerobic pathways that can be inhibited by NADH (3 pt)
_______________________________________ ____________________________________________
__________________________________________
B7). The TCA enzyme aconitase can be poisoned by a Nazi-developed poison called ____________________ (1 pt)
B8) Match the following enzymes with the appropriate statement. Use each answer once. (5 pt)
Note, each answer is used only once
i. pyruvate dehydrogenase (PDH) A. is activated by 3-phosphoglycerate (3PG)
ii. isocitrate dehydrogenase (IDH) B. is the committed step of TCA
iii. citrate synthase (CS) C. has an icosahedron shape
iv. -ketoglutarage dehydrogenase (KGDH) D. produces FADH2
v. succinate dehydrogenase (SDH) E. is inhibited by acetyl-CoA
(i) _____________ (ii) _____________ (iii)___________ (iv)___________ (v)___________
Draw the chemical structure of this enzyme’s product (five carbons) here (2 pt).
Score
(Do not
write in
here)
Total
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