CHEM 153A Study Guide - Final Guide: Pyruvate Dehydrogenase, Pyruvate Carboxylase, Carboxy-Lyases
15 Jun 2016
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The remaining 2 cs attached to s-coa -> acetyl-coa. Pdh catalyzes the conversion of pyruvate to acetyl-coa, a. Product and thus a competitive inhibitor bind to the active site. Pdh kinase phosphorylases pdh, inactivating it so binding to a. When the cell does not need to be breaking down glucose. = lots of atp or other carbon sources. = a build up of acetyl-coa (and nadh) = directly inhibit pdh + = high atp or low adp which leads to more active pdh kinase. Sources of acetyl-coa (stage 1 of cellular respiration) Which is why ac-coa is such a good regulatory molecule, communication between these three main sources of fuel. One of the pathways (enzyme) will function at the faster than the other 2 at a given time. An increase in [aa] or [fatty acid] may increase [acetyl-coa] => maybe inhibitors of pk. Pyruvate dehydrogenase (or pyruvate carboxylase) (multienzyme complex: e1: pyruvate decarboxylase fully oxidize the carboxylic group of.
