CHEM 153C Study Guide - Final Guide: Flavoprotein, Ketone Bodies, Isomerase
23 Jun 2016
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Fat t y acid + coa - sh + atp. Acyl- scoa + amp + ppi: acylation of carnitine, transport of fatty acids into the. Mitochondrion: b oxidation of fatty acids, formation of trans a-double bond. Associated with endoplasmic reticulum (er) or outer mitochondrial membrane. Reduces free [fatty acids]: intestinal fatty acid binding protein. Cleavage and synthesis of phosphoanhydride bonds (atp hydrolysis and acyladenylate formation): g ~0. Compartmentation (separation of catabolism and synthesis: mitochondria: oxidation. Nad+-dependent ehydrogenation: b-ketoacyl-coa (note: l- configuration of substrate only) Ca cb cleavage: b-ketoacyl-coa thiolase to form fatty acyl-coa. Short: c4 to c6: medium: c6 to c10 (mcad) Long: c8 to c14 (varies: very long: c12 to c18. Enzyme b : glu376 (general base in the hydrophobic microenvironment) Followed by the regeneration of fad: fadh2 undergoes redox reactions to transfer electrons to etf: electron-transfer flavoprotein to reduce coenzyme.
