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Midterm

LIFESCI 7A Midterm: LS7A Midterm #1 Practice ProblemsExam


Department
Life Sciences
Course Code
LIFESCI 7A
Professor
Maloy
Study Guide
Midterm

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LS7A Spring 2017 Midterm 1 Practice Problems
[Questions 1-2] The graph below shows the effects of two drugs on enzyme activity. For the following
statements mark A for true and B for false.
1. Drug A could be working as an allosteric inhibitor at all substrate concentrations.
2. Drug B could be working as an allosteric inhibitor at all substrate concentrations.
3. Based on the graph above, which Drug causes the enzyme to reach saturation at the lowest substrate
concentration?
A. Drug A
B. Drug B
4. Refer to the graph above. The drug is intended for patients who have enzymatic activity that is too
low, so the drug is used to increase enzyme activity. Which drug would be more effective for
treatment?
A. Drug A
B. Drug B
[Questions 5-6] Most patients respond well to treatment with the most effective drug (your answer to
question 4). However, one unusual patient responds poorly, and her enzymatic activity decreases even
further when she takes the drug. For the following statements mark A for true and B for false.
5. This patient’s substrate concentration is over 200 µM.
6. This patient’s substrate concentration is below 100 µM.
[Questions 7-9] Refer to the free energy diagrams below to answer the following questions. You may
assume that the y-axis is the same for all four reactions. Mark A for True or B for False.
7. Reaction C is endergonic.
8. Reaction B could be coupled to reaction D.
9. Reaction A should occur at a faster rate than reaction D.
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