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MCD BIO 90 Study Guide - Fall 2019, Comprehensive Final Exam Notes - Stem Cell, Cell Potency, Memory


Department
Molecular, Cell, and Developmental Biology
Course Code
MCD BIO 90
Professor
Mitra Hooshmand
Study Guide
Final

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MCD BIO 90

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Thursday, October 10, 2019
MCDB 90
Discussion 2!
-Similarities!
Look the same, potency, colony, functions, result of manipulation!
-Dierences!
ESCs!
-Source is limited, from the blastocyst, ICM!
-Younger, no epigenetic memory!
-Controversy, ethical concerns!
-Less risky!
iPSCs!
-Personalized — reduce the chance of rejection!
-Epigenetic memory — reprogramming is imperfect and inecient, the cells
are more likely to reverse to the previous cell !
-Any adult cells !
-c-Myc is related to cancer —oncogenes — you have to make sure that is
shut o and suppressed after!
-Viral vectors — break the genome — introduce proteins, or not permanently
changing the genome
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Monday, September 30, 2019
MCDB 90
Lecture 1-1!
-Diseases!
Alzheimer’s disease: neurons, oligodendrocytes!
-memory loss, recognition defect, disorientation, dimension disorder!
Parkinson’s diseases - dopaminergic neurons - motor control!
-shaking, increase risk-taking!
ALS - motor neurons!
-paralize, can’t move !
infertility - germ cells and a lot of other causes!
cardiovascular disease — cardiac cells !
-any tissues that infect heart and blood vessels!
-heart attack: lose blood flow and oxygen - cardiac cells !
deafness - hair cells!
diabetes - pancreatic cells, immune cells(auto immune), !
-type 1: genetic!
-type 2 : don’t respond to insulin!
multiple sclerosis!
-demyeliteating disease, don’t or slowly transmit the signals!
macular degeneration - retina ganglion cells!
stroke - neurons, brain tissues!
-oxygen not reaching your brain!
-brain tissues !
leukemia - immune cells!
sickle cells - red blood bells!
-clotting in the small blood vessels!
bubble boy disease / SCID - immune cells !
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