BIOL 1107 Study Guide - Midterm Guide: Acetyl-Coa, Pyruvate Dehydrogenase, Allosteric Regulation

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30 Oct 2018
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Occurs in cytoplasm, oldest part of cycle. Glucose + 2 atp + 2 nad+ 2 pyruvate + 2 nadh + 4 atp. Net output- 2 atp (2 are put back in), 2 nadh, 2 pyruvate. Kinases are enzymes that phosphorylate (use atp, transfer that phosphate to somewhere else) Phosphofructokinase uses 2 atp, phosphorylates fructose 6 phosphate fructose 1,6 bisphosphate. Negative feedback loop- to stop phosphorylation, atp that is produced comes back and binds to. Substrate level phosphorylation: enzymes and substrates are both used to transfer a phosphate to adp to phosphofructokinase, stopping it. Inputs: 6 nad+, 2 fad, 2 adp, 2 acetyl coa. Acetyl coa oxaloacetate (oaa) citric acid outputs- 2 co2, 3 nadh, 1 fadh2, 1 atp. Nadh inhibits cycle through competitive inhibition (binding to active site), white atp inhibits through (multiply everything by 2 because cycle spins twice) allosteric inhibition (binding to allosteric site)

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