MCB 2000 Study Guide - Midterm Guide: Sigmoid Function, Myoglobin, Storage Protein
10 Sep 2019
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At p50, hb is weaker than mb. Deoxyform (no o2 bound) is referred to as the t state. Fully oxygenated form (o2 bound) is referred to as the r state (relaxed state) tightly bound: how are the oxygen saturation curves different, cooperativity is the interaction between the r groups!! You can depict how tightly a protein is binding o2. If you have a value lower than p50 then the protein is tightly binding to o2 having a high affinity for o2 wants to keep its oxygen and has. If you have a value higher than p50 then the protein wont bind to the o2 as tightly at the same partial pressure: at p50 for mb. Curve rises sharply when partial pressure increases. This means that the mb quickly grabs onto the o2 and desperately holds on to it. At p50, the binding sites are at a relatively low value of 2 torr.
