PNB 2264 Study Guide - Quiz Guide: Voltage-Gated Potassium Channel, Computer Simulation, Resting Potential

• School: UConn
• Department: Physiology and Neurobiology
• Course: PNB 2264
• Professor: Kristen Kimball

Document Summary

Part i: the equilibrium potential and the membrane potential. Electrical potential difference between exterior and interior of the cell. Determined by: difference in ion concentrations of the intracellular and extracellular fluids. Inside is more negative than outside because the membrane separates the charges and there are more negative ions inside than outside. Na+, k+, cl- most abundant and control membrane potential: relative permeability of the cell membrane to the different ion species. Nernst equation: calculates at which voltage (electrical gradient) will equal the chemical gradient for the potassium to reach equilibrium. Just change the coefficient when you change the temperature: potassium tends to=-90mv. When the electrochemical gradient=-90mv, it opposes the. In resting stage, when channels open, k will want to leave the cell: when vm=-90mv. Electrical gradient is strong enough to oppose chemical gradient so the movement of k reaches equilibrium: when vm=-120mv. Electrical gradient wins, attracts k inside the cell.