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BIPN 100 Study Guide - Final Guide: Reflex Arc, Allostasis, Negative Feedback

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ambermallard232
11 Mar 2014
School
UCSD
Department
Biology/Animal Physiol & Neurosc
Course
BIPN 100
Professor
Kathleen French

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Document Summary

Negative feedback preserves the control and positive feedback magnitudes the variable: what is the difference between a mechanistic and teleological explanation, mechanistic - process. Teleological - end result: milieu interior - sum of all physiological variables in the body, what is a basic feedback loops, what are the two main cells of the nervous system. Glia - assist neurons: what are three things neurons do. Response: what are the four major types of reflex pathways, spinal - simple neural reflex muscle stretch reflex , simple endocrine. One is in the central portion and the other is in the peripheral: what is threshold, when you have graded potentials, they arrive at a neuron and create a. The cumulative effect of those must hit threshold value before an ap can be initiated. Minimum possible membrane voltage that can initiate an ap: true or false cells are either sensory receptor or integrating receptor, false - they can do both.

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Related Questions

g

Define: physiology, homeostasis, dynamic constancy, variable,range.

What are the four requirements for a feedback loop? Be able toexplain their role in feedback loops.

What is a negative feedback loop? What is a positive feedbackloop? Be able to give an example of each type of feedback loop.What is dynamic constancy?

Why are negative feedback loops preferentially used to maintainhomeostasis?

Why are antagonistic feedback processes used for negativefeedback loops?

Compare and contrast the two main regulatory mechanisms forhomeostasis (endocrine and nervous systems).

Know the organ systems and their functions and the differencesbetween exocrine and endocrine glands. This is more of a “keepthese in mind” rather than something that will be tested onLE#1.

What is the Law of Mass Balance?

How is blood glucose regulated?

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I. Signaling cascades (4 pts)

1. Which of the following is an example of a signaling cascade?

A. Binding of lactose to the lac repressor

B. Binding of the lac repressor to the lac operon

C. The series of proteolytic digests that occur during clotting

D. The Collins Toggle Switch

2. Why is it important that signaling cascades have negative feedback loops?

II. Metabolism (4 pts)

1. What is a benefit of a negative feedback allosteric regulator?

A. It prevents starting materials from being unnecessarily consumed.

B. It regulated metabolism without requiring new protein synthesis.

C. It can be rapidly reversed as conditions change.

D. All of the above.

2. How is a metabolic cycle, like the citric cycle, distinct from a metabolic pathway, like glycolysis?

III. Transcription (4 pts)

1. Transcription factors, repressors, and activators are examples of proteins that _________.

A. randomly activate RNA polymerases.

B. bind specific DNA sequences.

C. bind specific rRNA sequences.

D. are found in the lysosome.

2. The trp operon is attenuated by a stem-loop structure that can form near RNA polymerase. The RNA sequencing encoding the stem loop is:

5’-AUACCCAGCCCGCCUAAUGAGCGGGCUU-3’

The stem loop is composed of 7 nucleotides which perfectly base pair. Indicate the two halves of the stem loop on the sequence above.

IV. DNA replication/repair/genome editing (4 pts)

1. What is a consequence of the need for RNA primers during DNA replication?

A. Linear chromosomes gradually shorten each cell division.

B. Transcription factors often trigger DNA replication.

C. RNA primers are not actually needed for DNA replication.

D. Lagging strands can be avoided.

2. CRISPR-mediated genome editing has gene-specific components: an sgRNA, and a double-stranded repair template. Describe the role of the sgRNA in directing genome editing.

V. Genetic circuits (4 pts)

1. Which statement best describes the mechanism of the toggle switch?

A. Inducers must be continuously applied to maintain one of two states.

B. Competing repressors keep the cell in one of two transcriptional states.

C. An activator and a repressor keep the cell in one of two states.

D. A pair of repressors cause the cell to oscillate between two states without input.

2. How is bistability achieved by the Collins toggle switch?

Question #02: Membrane and Homeostasis / related events The question for this week is as follows: Select a homeostatic event and/or physiological system in which you can show the importance of structure/function relationship, organization levels, and feedback control. Your answer must follow the outline shown in the introduction (sub-questions a, b, c, d, see above). Please notice that in this question you select both the structure and the function on which your answer will be based. Hint: think on “the circle”.
a) Name the structure and the function on which your overall answer will be based? Be as specific as you can in delimiting the boundaries of your example (the most important part of your answer, since the following b, c, & d sub-questions are based on your answer to this first sub-question, a). Please notice that only 1 item is required (in your answer it should be labeled as “a”). This answer should look like: “a.- My structure (S) is …. and its function (F) is …”. In same cases a second sentence might be needed. b) Why do you think that your structure and your function are related? Support your contention based on 3 lines of evidence based on the chemistry, physics, anatomy, or physiology involved in your example. Please notice that 3 items are required (answers should be labeled as “b1, b2, and b3”). One of this answers might look like: “b1.- If I do this experiment and measure this variable using this technique, this result will suggest that my S/F is correct”. Please notice that MY question does not ask you to tell me what happens since this can be copy from any source, but it asked how do you know that your S/F relationship is true. c) Which are the levels of organization involved in your example (c1)? Cite events occurring at its main level of organization (c2) and indicate how they relate to the whole body level (c3). Please notice that 3 items are required (thus, answers should be labeled as “c1, c2, and c3”). These answers should look as follows: “c1.- molecular” or any level of organization involved in your “a” answer (S/F); “c2.- the first event is; the next even is; the middle event is; the next event is; the last event is”. Five events distributed equidistant from each other is a good summary for the story line of the your S/F named in your “a” answer. Finally, “c3.- at a whole individual level my S/F described in “a” plays this role”. d) Which are the main feedback mechanisms involved in your example (cite at least two) (d1)? Expand on one of them (d2) and name 2 absolute requirement for that feedback to work (d3). Please notice that 3 items are required (answers should be labeled as “d1, d2, and d3”). These answers should look as follows: “d1.- an increase in this negative feedback ligand must decrease this variable under control”. This is how you NAME a negative feedback. For d1 you need to name two negative feedbacks; “d2.- the first event is; the next even is; the middle event is; the next event is; the last event is”. Five events distributed equidistant from each other is a good summary for the most important negative feedback story line involved as a control of the your S/F named in your “a” answer, that you named in d1; “d3.- this two components are absolutely necessary for the negative feedback described in d2 to be operational.