MEDT270 Study Guide - Final Guide: Non-Gonococcal Urethritis, Bordetella, Lipid A

• School: University of Delaware
• Department: Medical Laboratory Sciences
• Course: MEDT270
• Professor: all

Document Summary

Normal microbiota- skin is not sterile: varies by body site due to varying environmental conditions, corynebacterium, propionibacterium, staphylocoous, etc. *staphylococcus aureus- normal microbiota in nostrils, not on skin surface: opportunistic pathogen- overall our resistance is fairly high, virulence factors: Contains protein a in its cell wall: binds to fc portion of igg: fc portion is responsible for biological activity of the antibody (if it binds here, it will neutralize the antibody; can"t bind to. Exotoxins- toxins secreted from the cell: can produce hemolysins & leukosidins. Attachment mechanisms- teichoic acid in cell wall: interacts with fibronectin (glycoprotein in our body, allow staph to stick and cause infection, glycolyx also allows staph to stick to cells surfaces, clinical manifestations. Most healthy people are resistant to infection. High risk individuals- diabetics, burn patients, neonates/elderly. Do cultures and identify bacteria, easily grown in lab: treatment. Usually beta-lactamase positive: methicillin resistant staph aureus (mrsa, affects drugs used for treatment- cannot use penicillins, etc.