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NSCI438 Study Guide - Midterm Guide: Autoimmune Disease, Sickness Behavior, Antibody

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Rosen Jeffrey
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Clinical Neuroscience Exam II Study Guide Psychoneuroimmunology
Psychoneuroimmunology = intersection in behavior, brain, and immune system
Skin: first and best line of defense
Mucosal membranes: covers vulnerable entry points
Innate immunity: first response if pathogen enters the body
o Respond similarly to all pathogens; do not learn from experience
o Macrophage: detect foreign chemical signals; reach out and engulf material;
expose material to lysosomes
o Histamines: lead to constriction of blood vessels to assist in clotting
Lead skin cells to constrict and leak cellular fluid, causing swelling
o Cytokines: alert other cells to invasion; facilitate communication
o Neutrophil: 70% of white blood cells, die by apoptosis
Decomposed, make up puss, release lysosomes
o Natural killer cells kill invading/infected cells
Release perforin
Cocktail of enzymes that opens up cells; deposits enzymes into the
cell and triggers apoptosis
Acquired immune system: slower response time; learns from exposure
o Immune system involved with vaccinations
o B cells: originate from bone marrow cells
Can produce antibodies; each B cell only produces one type of antibody
o Antibodies: wait to encounter pathogen, bind to antigens
Antigens: molecule of a pathogen
o T cells:
Helper T cells: produce cytokines to activate macrophages
Stimulate release of antibodies from B cells
Require assistance of antigen presenting cell
Killer T cells: destroy virus infected cells
Use perforin to trigger apoptosis
Also send cytokines to the rest of the immune system
Immune disorders:
o Overactive = allergies, arthritis
Autoimmune disorders = MS
Experiment: paired nausea-inducing drug with sugar water
o The drug is also a known immune suppressant
o Immune system became conditioned suppressed when exposed to sugar water
Nerve fiber extend to immune related tissues
Leukocytes: produce endorphins and ACTH
o Have neuropeptide receptors
o Can send and receive messages
“sickness behavior”
o i.e. fever
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