i Clicker Questions:
1) The self renewal signaling pathway in a particular stem cell type has an additional kinase,
TK3 that inactivates (dephosphorylates) TK1. TK3 is produced from the expression of a gene
activated by TFa. How would TK3 change the behavior of the pathway?
A. It would become a temporary circuit, even when signal is present.
B. It would become a permanent circuit, even when signal is absent
C. It would not change.
Temporary -> Circuit is inhibited at TK1
Permanent -> Full cycle, all 4 steps.
2) You analyze a stem cell and get the following results.
Signal Present =
Receptor Present Y
TK1 Present Y