PHYS 135a Midterm: PHYS 135 USC 042Midterm1
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Schlessinger"s structural data shows an alternative mechanism, which you should explain. (question given in class, answer in assigned reading) answer: Oh: (10 pts) the mechanism for phospho-ester hydrolysis by protein tyr phosphatases is used by about 100 enzymes that dephosphorylate proteins as well as lipids. In the box below diagram the two step mechanism and label which step is fast and which step is slow. Be sure to include the 3 residues critical for catalysis that are conserved at the active site of all these enzymes. 1: (5 points) the receptor tyr kinase (rtk) family was depicted in a diagram (shown here) in the assigned readings and discussed in lecture. Red highlights the n terminal lobe made mostly of. Blue highlights the c terminal lobe made mostly of. Each of these has one primary intracellular receptor protein that binds 4 molecules of second messenger to activate pathways to transduce the signaling.
