BIO 325 Study Guide - Final Guide: Somatic Cell, Site-Specific Recombination, Lac Repressor

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28 Dec 2017
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Final exam study guide bio 325 genetics, saxena (fa17) Genotyping multiple polymorphic loci such as ssrs produces enough info to distinguish individuals based on dna. Dna microarray has allele-specific oligonucleotides (asos) for millions of snp loci. With proper conditions, probe of fluorescent genomic dna fragments can be affixed to complementary asos and allow the loci to be genotyped. Before replication, each eukaryotic chromosome has a single linear, double-stranded dna without breaks or changes in polarity. Histone proteins help package dna into chromatin, while nonhistone proteins do many other things, such as function in chromosome structure, replication, segregation, and control of gene expression. In a nucleosomes, dna wraps twice around a histone core of h2a, h2b, h3, and h4. Histone h1 controls entry and exit of dna. Higher-order compaction models suggest that the nucleosomal fiber gets supercoiled into a shorter but wider fiber.

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