BCH2011 Chapter Notes -Carbonic Anhydrase, Facilitated Diffusion, Hydrophile

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The solute moves by simple diffusion from the region of higher concentration, through the membrane, to the region of lower concentration, until the two compartments have equal solute concentrations. When ions of opposite charge are separated by a permeable membrane, there is a transmembrane electrical gradient, a membrane potential, vm. This membrane potential produces a force opposing ion movements that increase vm and driving ion movements that reduce vm. Thus, the direction in which a charged solute tends to move spontaneously across a membrane depends on both the chemical gradient (the difference in solute concentration) and the electrical gradient (vm) across the membrane. Together these two factors are referred to as the electrochemical gradient or electrochemical potential. Membrane proteins lower the activation energy for transport of polar compounds and ions by providing an alternative path across the membrane for specific solutes.

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