BMS1062 Chapter Notes -Homologous Recombination, Plasmodium, Glycoprotein

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Recombination: the process in which dna molecules are broken and the fragments are re- joined in new combinations. This can occur in living cells: crossing over during meiosis. In vitro by use of dna and enzymes that can break (restriction enzymes) and join (ligases) the dna fragments. Based on inherited traits passed on from parents. Specific receptors on surface of phagocytic cells which can recognise pathogen structures. A 2nd encounter with an antigen leads to a greater and more rapid immune response. Involves white blood cells called lymphocytes : t lymphocytes or t cells . Cellular immunity: b lymphocytes or b cells . T cells are on the membrane and never secreted from the cell whereas b cells are secreted. Each lymphocyte bears a single type of antigen receptor with a unique specificity. Generated during development prior to antigen exposure. Upon infection, a lymphocyte clone will display a receptor with the appropriate specificity to recognise the antigen.

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