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CHEM 1004 (13)
Chapter 15

Chapter 15

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CHEM 1004
Gerald Buchanan

Chapter 15: Antacids - Additional OTC Drugs ● Antacid Medications - Mostly OTC, but prescription needed for acid reflux drugs ● pH - the symbol for acidity, represents the 'power of the Hydrogen (or Hydronium) ion' ○ The pH of a solution is a measure of the acidity of that solution. ● pH of Neutral Water ○ Molarity (moles/L) of the proton(hydronium ion). -7 ○ [H3O+] or [H+] = 0.0000001M = 1 x 10 M pH = - log Express concentration. as power of 10 = - log(10 ) Reverse the sign = +7 ● The pH of an acidic solution is less than 7. The pH of a neutral solution equals 7. The pH of a basic solution is greater than 7 ● pH of 1 is 10 times more acidic than a pH of 2 and 100 times more acidic than a pH of 3. A pH of 14 is 10 times more basic than a pH of 13 and 100 times more acidic than a pH of 12 ● Alka Seltzer - Effervescent antacid and pain reliever! ○ Hydrolysis of sodium bicarbonate produces a weak acid H C2 (N3OH), so the resulting solution is basic and a strong base ● TUMS (for the stomach) - Other over the counter drug ○ Active ingredient is CaCO3insoluble in water, so it is in a chewable form ● Pepcid - Active ingredients: CaCO (800mg) andMg(OH) ; 165mg per tablet. 3 2 ○ Maximum 2 per day ○ Also chewable due to low CaCO3 solubility ● Put sugar in chewable tablets to make them taste better ● Baking soda: ○ Is pure sodium bicarbonate NaHCO 3 ○ When dissolved in water, no evolution of at room temperature. ○ Need acid to cause this evolution (ie citric acid) from the lemon, acting on the powder ● Arm & Hammer Baking soda ○ Contains only sodium bicarbonate powder ○ Can be used as an OTC antacid for acid indigestion only but, it is High sodium, and since CO 2iven off when combined with stomach acid, it can cause acid reflux ● pH of Blood: ○ If pH drops, eg. during illness, the3[H O+] begins to increase but will react with HCO -3to form H 2O ,3ie. CO 2 which is exhaled. Or the reverse if pH of blood drops. ○ [H CO ] is maintained by exhaling / inhaling CO 2 3 2 ● LeChatelier’s Principle: ○ H2O + CO, -> H 2O 3 ○ If more CO2 is produced (ie hyperventilation) , then body reacts to produce
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