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CHEM 1004 (13)
Chapter 14

Chapter 14

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CHEM 1004
Gerald Buchanan

Chapters 14 - Non Steroidal anti inflammatory drugs (NSAIDS) - Most common use is the alleviation (relief) of pain 4 Most Common Drugs: 1. Aspirin (acetylsalicylic acid) a. Reduce pain, thin blood, reduce chance of colon cancer b. Enterically coated aspirin - Has some coating on it so it doesn’t dissolve in the stomach but instead the intestines to avoid stomach irritation c. Varies in effects but is remarkably safe when not overused. ~5% have some intestinal bleeding. Can cause problems in adults when used frequently and in quantity but, the risk is greater in children (Use acetaminophen instead. d. Anti-Inflammatory effects of aspirin: Ex. rheumatoid arthritis, inflammation of fingers toes, knees, etc, is factored by prostaglandins (induce pain, blood clotting). The aspirin inhibits prostaglandin synthesis 2. Acetaminophen (Tylenol) *Technically not as NSAID a. Alternative anti-pyretic due to the bleeding risks of aspirin b. A “coal tar” anagelestic (aniline) c. No anti-inflammatory effects d. Advantages over Aspirin i. No tendency to induce bleeding because its not a blood thinner ii. Less potential for nausea and can be used if allergic to aspirin e. Disadvantages: i. Non anti-inflammatory ii. Potentially toxic to liver and kidneys iii. Combined with alcohol = increased risk of liver damage iv. Extra strength over long periods can induce hepatitis 3. Ibuprofen (Advil or Motrin) a. Effective at lower doses (~⅓) than Aspirin and acetaminophen b. Effective against menstrual pain c. Should NOT be taken by children if a viral infection is suspected d. Antipyretic, analgesic, anti-inflammatory
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