NEUR 1201 Chapter Notes - Chapter 3: Radial Glial Cell, Sonic Hedgehog, Neural Tube
22 Feb 2018
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3. 1 the same gene may play a role in many different developmental events. Pleiotropy occurs when one gene influences many different traits (especially when traits seem unrelated: ex. Sonic hedgehog helps with floor plate, motor neuron differentiation and optic cups: with respect to ge(cid:374)e i(cid:374)flue(cid:374)ces, it"s the (cid:374)or(cid:373) Redundancy several genes contribute to producing a single trait: ex. Several proteins from dorsal lip of blastopore organize induction of neural plate: loss of one of these genes only has a modest effect. 3. 2 the developing brain generates neurons at a tremendous rate. Gliogenesis production of new glia (happens throughout life: glial cells can divide to produce new glial cells. As more cells break out of mitotic cycle, they accumulate beneath outermost marginal zone and above ventricular in the intermediate zone. 3. 3 shortly after division, neural cells diverge to become neurons or glia. Differentiation of neural cells into particular neuronal or glial fates is primarily influenced by cell cell interactions.
