PSYO 2570 Chapter Notes - Chapter 7: Paracrine Signalling, Protein Kinase, Endocrine System
12 Oct 2018
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Document Summary
Molecular signaling mediates and modulates all brain functions. Paracrine signaling: involves secretion of chemical signals onto a group of nearby cells; endocrine signaling: refers to the secretion of hormones into the blood stream, which can affect targets throughout the whole body. Chemical signaling requires 3 components: signal information transmitter. Effector molecule that mediates the cellular response. A general advantage of chemical signaling is signal amplification. (a single cell can cause responses in many other cells). The complexity of these signaling permits precise control of cell behavior over a wide range of times. Signaling molecules can be grouped into 3 classes: cell impermeant. (must bind to extracellular portions of receptor proteins) Cell permeant. (are able to cross the membrane freely to bind with receptors located in the cell) Cell-associated signaling molecules. (these signals are attached to the cell) Cellular responses are determined by the presence of receptors that specifically bind to the signaling molecules.
