PHGY 313 Chapter Notes -Ion, Common Bile Duct, Heme Oxygenase
17 Jul 2013
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Shouldn"t be able to touch liver from under the ribs unless you have hepatitis. Common bile duct and pancreatic duct fuse and spill into the 2nd stage of duodenum through the ampulla of vater (controlled by sphincter of oddi) Pain after meal in upper r epigastric region. After you eat food, cck release is stimulated by fatty acids in the duodenum (apud cells, specifically i cells). Cck causes gall bladder contraction and bile is secreted. Stones block the duct, causing an increase in pressure. Pain receptors in wall of gall bladder you get gall bladder distension and pain. Gall stones can be made of cholesterol, bile pigments, and ca2+. Expand on the metabolism of the pigment causing the jaundice in this patient. Backflow in liver because of obstruction of common hepatic duct. The catabolism of heme makes biliverdin (greenish) via heme oxygenase. Bilirubin binds to glucoronic acid in 1:2 ratio. Jaundice occurs when plasma bilirubin reaches 34 moles/l.
