BIOCHEM 2EE3 Chapter Notes - Chapter 2 & 3: Van Der Waals Radius, Relative Permittivity, Coordination Complex
2 Feb 2016
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Document Summary
Noncovalent interactions are critically important determinants of biomolecular structure, stability, and function. The helical double stranded shape of dna is stabilized by multiple noncovalent ineractions. The folded conformation of proteins is stabilized by many noncovalent interactions. Noncovalent interactions are 10 to 100 times weaker than covalent bonds allows them to continually be broken and reformed. E. g human growth hormone (hgh) binds to its receptor, which transmits a signal across the cell membrane. These noncovalent interactions are naturally electrostatic in nature depend on the forces that electrical charges exert on one another. The simplest electrostatic interaction between two ions, aka ionic bonds: the cell contains an abundance of small ions, both cations (na+, k+, mg2+) and anions (cl- and hpo4/2-) Screening effect: the existence of a medium in. Real life that these ions are surrounded by, which causes the actual force between the ions to be less than coulomb"s law.
