BIOLOGY 2F03 Chapter 9-10: Staging of HL
20 May 2018
School
Department
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Professor
1. Staging of HL
• Staging is based on
o Examination
o CXR
▪ mediastinal widening, hilar LNpathy
o CT
o PET (more useful for monitoring disease after follow up)
• Staging is 1,2,3,4 depending on structures involved either side of diaphragm (+A/B)
2. Treatment of HL
• Combo involved field radio and chemo
(ABVD/BEACOPP)
• Use PET to monitor disease after 2 cycles
• ?Anti CD20 in nodular HL
• ?Anti CD30 in classical HL
• Treatment SFX = toxicity, malignancies, CVD
3. Prognosis of HL
• Median survival untreated in less than a year
• 5 year survival of early stage HL is now >90%
• Prognostic factors are:
a. Disease stage
b. Age
c. Albumin
d. Lymphocyte count
e. LDH
f. ESR
