BIOLOGY 2F03 Chapter Notes - Chapter 9-11: Mantle Cell Lymphoma, Mantle Zone, Lymph Node
20 May 2018
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1. Strengths, weaknesses of molecular techniques
Ads - reproducible, applicable to 90% of cases, sensitive, becoming more cost effective
Disads - requires molecular expertise, can be laborious
2.22 - LYMPHOMA - DLBCL & MCL (this lecture was not actually given)
Not sure if this lecture was given or not
1. Pathogenesis in lymphoma
• Mutations that confer survival advantage/clonal proliferation early in the lymphoid ontogeny leads
to:
o ALL
o Precursor B/T cell lymphoma
• Mutations that occur later in the ontogeny leads to:
o CLL
o Mature B/T cell lymphoma
• 85% of lymphoma is non-hodgkins, i.e. reed-sternberg cells are absent
2. Structure of a lymph node
• The outer layer (PARACORTICAL) contains T cells
• The inner layer in the lymphoid follicle:
o the germinal centre is where B cells bind antigen and become activated
o the surrounding mantle zone still contains naïve, unstimulated, virgin b cells
3. Clinical features of lymphoma
• Presentation
o proliferation of lymphocytes in tissues =
▪ lymphadenopathy (+/- local compression/ obstruction)
▪ hepatosplenomegaly
▪ High WCC
▪ Leukostasis
o Proliferation of (immature) blasts in BM =
▪ Anaemia, neutropenia, thrombocytopenia
o B symptoms
• Diagnosis/staging - BM/ LN biopsy, PET scan
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