BIOLOGY 2F03 Chapter Notes - Chapter 33: Mycosis Fungoides, Acute Lymphoblastic Leukemia, Barbara Bain
20 May 2018
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2.35 - PATHOLOGY OF NON-HODGKIN LYMPHOMAS
1. WHO classification of lymphoma
B NHL
T NHL
Low Grade
SLL (small lymphocytic lymphoma)
MCL
Follicular
MALT
Mycosis fungoides
High grade
DLBCL
Burkitts
Lymphoblastic lymphoma
Anaplastic
ATLL
enteropathic
2. Clinical features of NHL (largely a repetition from previous Barbara bain lecture)
D - a lymphoma without the presence of reed-sternberg cells
I -on the up due to increasing AIDS & more frequent SCTs (immunosupression)
A - mean = 42
S - M>F
G
A - Immunodeficiency (AIDS, SCT)
AI disease (RA, SLE)
Chromosomal abnormalities
▪ T14/18 = follicular
▪ T11/14 = mantle
▪ T8/14 = burkitts
Infections (EBV, HIV, HTLV1, H.Pylori)
Chemicals (AAs, radiation)
Inherited factors/ familial and racial trends
P -excised lymph nodes usually display diffuse whiteness and increased size
C - insidious (especially with low grade) lymphadenopathy with or without B symptoms
- tumour bulk can impact local structures
- lymphomas can invade BM (anaemia, neutropenia, thrombocytopenia)
- you can get autoimmune disease with some lymphomas
Diagnosis - FNA cytology can be useful in those that have spread to blood, but otherwise you
need LN excision biopsy under GA
P - depends on age, LDH, staging, extranodal involvement(s). some molecular and histological
markers can also determine prognosis
3. Low grade lymphoma vs high grade lymphoma
LOW GRADE
HIGH GRADE
Indolent/ slow progression
Aggressive/rapid progression
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Document Summary
2. 35 - pathology of non-hodgkin lymphomas: who classification of lymphoma. A lymphoma without the presence of reed-sternberg cells. On the up due to increasing aids & more frequent scts (immunosupression) M>f: clinical features of nhl (largely a repetition from previous barbara bain lecture) Chromosomal abnormalities: t14/18 = follicular, t11/14 = mantle, t8/14 = burkitts. Excised lymph nodes usually display diffuse whiteness and increased size. Insidious (especially with low grade) lymphadenopathy with or without b symptoms. Lymphomas can invade bm (anaemia, neutropenia, thrombocytopenia) You can get autoimmune disease with some lymphomas. Diagnosis - fna cytology can be useful in those that have spread to blood, but otherwise you need ln excision biopsy under ga. Depends on age, ldh, staging, extranodal involvement(s). some molecular and histological markers can also determine prognosis: low grade lymphoma vs high grade lymphoma. Can occur at any age: b cell nhl.
