BIOLOGY 3UU3 Chapter 1-20: 3UU3 articles
26 Sep 2016
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Maternal methyl supplements in mice affect epigenetic variation and dna methylation of offspring- Dna methylation and epigenetics: control by dna methylation. Inhibited by reaction product sah, some are zinc finger enzymes: maternal nutrition adequate for producing offspring with normal growth and reproduction is not necessarily the optimal balance for offspring"s long-term health and longevity. Yellow or mottled yellow coat color, altered metabolism and obesity from a young age. Animals and epigenetic phenotypes: ectopic agouti gene expression produces the yellow agouti obese mouse syndrome, offspring produced by a/a with avy/a matings, degree of mottling of coats was visually estimated. Maternal diet studies: three levels of diet were used control, mid-range methyl supplemented and high level methyl supplemented including supplemented zinc and methionine. Dna methylation: sites in the ltr containing cpgs were used as targets to assay dna methylation. Maternal diet and the distribution of epigenetically determined phenotypes of offspring: shift in distribution toward phenotypes with more agouti coat as increasing levels.
