BIOLOGY 3UU3 Chapter Notes - Chapter 11: Dna Methyltransferase, Mecp2, Methylation
13 Apr 2017
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Maternal methyl supplements in mice after epigenetic variation and dna methylation of. The study investigates whether maternal dietary methyl supplements will increase. Dna methylation and methylation-dependant epigenetic phenotypes in mammalian offspring. Offspring in study vary in phenotype, health, and 2-y survival. Methyl supplements increased the level of dna methylation in the agouti ltr and changed phenotype of offspring in the healthy, longer-lived direction. Factors such as diet, lifestyle, genetics, and epigenetics can influence health and life span of mammals. In rodents, these parameters can be minimized, but there are still considerable variances in health and life span. C57bl6 mice and fischer 344 rats which are highly inbred (and therefore have very little genetic variation, are good test subjects) In such cases, studies have been done where animals receive the same food, maintained at same temperature, humidity, etc yet longevity is still highly variable. => due to epigenetic variation within the species.
