CHEM 1AA3 Chapter Notes -Cell Nucleus, Heterocyclic Compound, Combinatorial Chemistry
19 Sep 2013
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Queen pheromone blocks aversive learning in young worker bees. Queen mandibular pheromone (qmp: causes young workers to feed and groom her, suppresses new queens, controls colony behaviour. Qmp contains homovanillyl alcohol (hva: hva suppresses bad memories, but not good ones. Biological role: mitigates unpleasant side effects of qmp. Significance: hva lowers [dopamine, dopamine is associated with learning. Therapeutic potential: high [dopamine] in some psychoses & schizophrenia, hva-like molecules could be treatments but, need high specificity. Attention deficit disorder & parkinson"s disease are linked to low [dopamine] Global suppression of [dopamine], or suppression in the wrong parts of the brain, could have undesired side effects. Key concepts: queen bees control worker bees memories using hva, help understanding human learning, develop new therapeutics. 1 new drug requires ~5000 failed compounds. Improving synthesis & accelerating assays facilitates drug discovery. High-throughput screening (hts: fast way to assay for a complex biological response. 2 components: a fast assay, massively parallel assays.
