HTHSCI 3I03 Chapter Notes -Immunoglobulin Class Switching, Lymphatic Vessel, Fc Receptor

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 3I03
• Professor: Jonathan Bramson

Document Summary

Neutralization, opsonization, mediates nk cell killing (adcc) and classical complement activation. Ab= can also activate your mast cells crosslinks mast cells release your granules etc Human= igm, igd, igg (igg1,2,3,4), iga (iga1,2) Na ve b-cell will enter the ln from the blood. Can go back to the bone marrow. Three differences to remember about antibodies: isotypic differences= i. e. igg vs. iga, allotypic differences= based on a polymorphism in the constant region, idiotypic differences= differences in the epitope binding. Igm= easiest to produce, no isotype switching, good at classical complement activation, can also do a little bit of opsonization and neutralization. Igg= highest circulating ab, neutralization, opsonization, adcc, can activate complement. Iga= very good at neutralization, found in mucosal sites (i. e. in the gi tract), minor functions= can opsonize and activate complement. Ige= allergy association (mast cell sensitization/activation), parasitic infections mast cells are helpful. Blood= igg and igm (note: igg can pass the placenta)