NURS 2004 Chapter Notes - Chapter 6: Salbutamol, Sodium Bicarbonate, Vomiting
28 Jan 2017
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Occurs anytime a patient takes more than two drugs. Some drug interactions are desired and intended as we use multiple drugs to treat one disorder (hypertension) while others are not desired and not intended. 3 possible outcomes of drug-drug interactions: (1) intensification of effects: One drug may intensify the other, known as potentiative. Increased therapeutic effects: administering a drug that undergoes rapid inactivation by enzymes and administering another drug to inhibit those enzymes, thereby intensifying and prolonging therapeutic effects. One drug might reduce the effects of the other, known as inhibitory. Reduced therapeutic effects: can cause therapeutic failure (propranolol and albuterol) Reduced adverse effects: drugs that reverse or correct overdose from drugs (naloxan & Might produce a new response not seen with either drug alone. Taking alcohol and drug used to treat alcoholism can create host of unwanted responses. Mechanisms of drug-drug interactions: direct chemical or physical interaction. Most commonly in iv solutions. (sometimes a precipitate forms: pharmacokinetic interaction.
