BCHM 316 Chapter Notes - Chapter 12.3: Cholesteryl Ester, Lipoprotein Lipase, Chylomicron
23 Feb 2018
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Almost all triglycerides - also has phospholipids, proteins, free cholesterol. Has the most: triglycerols (85, phospholipids (9, cholesteryl esters (3, protein (2, free cholesterol (1) Outside: phospholipid shell (mono-layer), cholesterol, and postage stamp proteins. Apo-cii key protein, activates lipoprotein lipases, identifies chylomicron. Has more cholesteryl esters, more phospholipids, more free cholesterol and proteins. Nearly identical structure: core of triglycerides and cholesteryl esters; outer monolayer of phospholipids , also has apo-cii (recognition apolipoprotein that activates lipoprotein lipase) Cholesterol: has steroid nucleus, lipid - soluble, has a polar-head group (not ionized-always -oh) Cholesteryl esters: fatty acid covers polar head group, so the particle is lipid- soluble. In peripheral tissues, apo-cii on chylomicron activates lipoprotein lipase, which removes fas from glycerol. Lipoprotein lipase: located in adipose, muscle, and peripheral tissues. Only works on tg in vldl and chylomicrons (have apo-cii) ** apoc-ii = recognition protein in lipoprotein particle, recognized by lipoprotein lipase.
