BCHM 316 Chapter Notes - Chapter 13.2: Cholesteryl Ester, Lipoprotein Lipase, Carboxylic Acid
23 Feb 2018
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As a fa enters a mitochondria, it is broken down. ( it doesn"t leave). Fas on albumin and glycerol are exported to liver and/or muscle. Fas are weak acids, ionized at cellular ph (~7). However, 95% is bound in blood/cell. (so free carboxyl group is tied up). Fa can be coming off albumin or action of lipoprotein lipase (which breaks down triacylglycerol and cholesteryl esters). A fa transporter is embedded in the cell membrane. If ionized, won"t cross membrane so we need a transporter. The transporter also increases the speed of the nonionized form. (even though the nonionized form doesn"t require a transporter to pass through). We do not want fa to remain in the free form - because it is reactive. Energized coa can combine with fa to create fatty acyl coa. A thiokinase is a ligase that synthesizes coa thioesters. In this case : fatty acyl-coa is a coa thioester.
