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Chapter 14.3*

BCHM 316 Chapter Notes - Chapter 14.3*: Acetyl-Coa, Beta Oxidation, Thiolase

Course Code
BCHM 316
Glenville Jones

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There are 4 steps involved in the B-oxidation of fatty acids
1. Oxidation
2. Hydration
3. Oxidation
4. Cleavage
Biosynthesis goes in the opposite direction of B-oxidation so..
1. Condensation
2. Reduction
3. Dehydration
4. Reduction
Oxidation can be termed dehydrogenation because we are taking away H+ in
terms of reducing power.
1. Oxidation: Fatty acyl coA
- Enzyme: acyl-coA dehydrogenase
- FAD enters and exists as FADH2 (so a H+ is being removed from the
fatty acyl-CoA)
2. Hydration: Trans-delta^2-Enoyl-coA
- delta^2 because double bond
- Enzyme: enoyl-coA hydratase
- H2O enters
- The double bond at carbon 2 is gone
3. Oxidation: 3-L-hydroxyacyl-CoA
- Enzyme: 3-L-hydroxyacyl-CoA dehydrogenase
- NAD+ enters and leaves as NADH and H+
- That means two hydrogens have left
4. Cleavage: B-ketoacyl-CoA
- Enzyme: B-ketoacyl-CoA thiolase
- CoASH enters
We now have Fatty acyl coA (like the beginning, but two carbons shorter) and
acetyl coA
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