BCHM 316 Chapter Notes - Chapter 14.2*: Malonyl-Coa, Acetyl-Coa, Electron Acceptor

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Comparison of Fatty Acid B-oxidation and Fatty Acid biosynthesis
B-oxidation
Biosynthesis
Where does it occur?
mitochondria
cytoplasm
Acyl group carrier
CoA
ACP
FAD = electron acceptor
NADPH = electron donor
L or D configuration for
the hydroxyacyl group
L
D
NAD+ = electron
acceptor
NADPH = electron donor
Does it have electron
donors or electron
acceptors?
Electron acceptor
- The molecule loses
H+; being accepted
by the acceptor
Electron donor
- The molecule gains
H+ (synthesis) ;
being donated by
the donator
C2
Unit product:
acetyl -CoA
Unit donor:
malonyl-CoA
ACP resembles CoA, but is
different!
FAD is an electron acceptor; the reaction goes from Fatty-
acyl CoA to Enoyl-CoA.
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Hydrogens leave the molecule.
FAD =Electron acceptor because it gains hydrogens to become FADH2
NADPH as an electron donor; the reaction goes from
Enoyl-ACP to Fatty acyl-ACP! Hydrogens are
inserted into the molecule.
NADPH + H+ = electron donor because it loses
hydrogens to become NADP+
NAD+ is an electron acceptor; the reaction
goes from 3-L- Hydroxyacyl CoA to B-
ketoacyl-CoA.
Hydrogens leave the molecule.
NAD+=Electron acceptor because it gains
hydrogens to become NADH + H+.
NADPH as an electron donor; the reaction goes
from B-Ketoacyl-ACP to 3-D-Hydrocyacyl-
ACP! Hydrogens are inserted into the molecule.
NADPH + H+ = electron donor because it loses
hydrogens to become NADP+
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Document Summary

Comparison of fatty acid b-oxidation and fatty acid biosynthesis. Fad = electron acceptor nadph = electron donor. L or d configuration for the hydroxyacyl group. H+ (synthesis) ; being donated by the donator. Fad is an electron acceptor; the reaction goes from fatty- acyl coa to enoyl-coa. Fad =electron acceptor because it gains hydrogens to become fadh2. Nadph as an electron donor; the reaction goes from. Nad+ is an electron acceptor; the reaction goes from 3-l- hydroxyacyl coa to b- ketoacyl-coa. Nad+=electron acceptor because it gains hydrogens to become nadh + h+. Nadph as an electron donor; the reaction goes from b-ketoacyl-acp to 3-d-hydrocyacyl- Nadph + h+ = electron donor because it loses hydrogens to become nadp+ The c-2 unit product: is the two-carbon acetyl-coa. The c-2 unit donor: is the three-carbon malonyl-coa. The advantage of having two kinds of enzymes is regulation! We can run these two processes at the same time if we wanted to !

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