BCHM 316 Chapter Notes - Chapter 14,15: Phosphorylase, Uridine, Phosphorylase Kinase
10 Aug 2016
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What: noncarbohydrate precursors glycogen: ex. lactate, glucogenic amino acids. Why: many tissues are dependent on glucose as their energy source: ex. brain and erythrocytes. Where: mainly in liver, lesser extent in kidney cortex: storage in liver and muscle cells anabolic process energy is needed! Function and precursors: liver converts precursors to glucose, where it is then exported: lactate glucose lactate pyruvate oxaloacetate pep, alanine glucose pyruvate oxaloacetate malate oxaloacetate pep, glycerol glucose. *** note the last step requires two enzymes to reverse the one enzymatic step of glycolysis*** Liver subtype hexokinase iv (glucokinase: best when [glucose] > 5mm, allows liver to metabolize excess glucose, not inhibited by glu 6p, moves into cell when glucose is present (regulation allows removal of excess glucose) Muscle subtype hexokinase i and ii: insulin dependent/upregulated (activity increased by insulin, inhibited by glu 6p. Adp and amp stimulate when [glucose] = low.
