BLG 151 Chapter Notes - Chapter 10: Riboswitch, Corepressor, Repressor
19 Jan 2018
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Chapter 10 study notes for microbiology: control of the expression of genes. Regulation- proteins can control whether mrna is made or not (stop transcription initiation) Riboswitch- specialized form of attenuation: translational control. Repressor proteins that prevent translation form starting. Riboswitch that binds to a metabolite: post translational control. Initial information about gene expression came from studying sugar metabolism in bacteria (example: e. coli bacteria: (cid:272)oli used glu(cid:272)ose a energy sour(cid:272)e (cid:271)ut if it wasn"t available it could use another sugar such as lactose, maltose, or sucrose. But enzymes to break down those sugars were not present when glucose was present/available. Negative control- involves binding of a repressor protein to dna to stop transcription initiation. Positive control- involves binging an activator protein (regulator protein) to dna to help transcriptional initiation. Repressor proteins and activator proteins can be in active or inactive states. Repressor binds to the target gene on dna to stop transcription.
