CHY 205 Chapter Notes - Chapter 15: Rate-Determining Step, Metabolic Control Analysis, Glycogen Synthase

• School: Ryerson University
• Department: Chemistry
• Course: CHY 205
• Professor: Mario Estable

Document Summary

Metabolic regulation is essential in that all rxns are regulated in some form. *when any cell uses glc 6-p for 1 purpose, that affects all other pathways it"s a. Modifying activity of existing molecules precursor in, in that any change in the allocation of glc 6-p to 1 pathway, in/directly affects the flow of metabolites through all others. Cells & organisms maintain a dynamic steady state: cells & organisms exist in metabolic homeostasis, eg. 5mm [blood glc]. The failure of homeostatic mechanisms is often the root of human disease. In the course of evolution, organisms have acquired a collection of regulatory systems from maintaining homeostasis at the molecular, cellular & organismal levels. A typical eukaryote has the capacity to make 30,000 diff pro which catalyze 1000s diff rxns involving many 100s of metabolites, most shared by more than 1 pathway creating this metabolic map.