PAT 20A/B Chapter Notes - Chapter 22: Low-Density Lipoprotein, Coronary Artery Disease, Vascular Smooth Muscle
27 Oct 2016
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Chapter 22: disorders of blood flow in the circulation systemic circulation. Form the lining of the vascular system. Semipermeable membrane, controlling transfer of substances across the vessels. Controls platelet adhesion and blood clotting, modulation of blood flow and vascular resistance, metabolism of hormones, regulation of immune and inflammatory reactions, and elaboration of factors that influence the growth of other cells. Several types of potentially reversible changes in endothelial function that occur is response to environmental stimuli. Can reduce the availability of nitric oxide thus reducing vasodilation, or increase in endothelins thus increasing vasoconstriction. Dysfunctional endothelial cells produce other cytokines, growth factors, procoagulant or anticoagulant substances and other biologically active products. Form the predominant cell alter in the tunica media. Cholesterol important structural bases for bile salts, plasma membrane and hormones. Elevated cholesterol in implicated in the development of atherosclerosis. Transport cholesterol and triglycerides to tissues for energy use, lipid deposition, steroid hormone production, and bile acid formation.
