PAT 20A/B Chapter Notes - Chapter 18: Exudate, Blood Vessel, British Association For Immediate Care
2 Oct 2018
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Document Summary
Inflammation is a protective response that is meant to rid the body of the initial cause of cell injury, remove damaged tissue, and generate new tissue. Vascular tissues response to cell injury or death. Involves mediators and the movement of fluid and wbcs from the blood into extravascular tissues. It localizes and eliminates pathogens and paves the way for regeneration. Two types: acute and chronic: acute: triggered by infection or tissue injury; rapid onset; short duration; exudate and. Wbc emigration (noots: chronic: longer duration; proliferated vessels; necrosis; fibrosis. Selectively permeable barrier to exo- and endogenous stimuli. Regulate wbc leakage by expressing cam and receptors. Regulate and modulate immune response through mediators. Growth factors stimulate angiogenesis and matrix synthesis. Release mediators increase permeability and alter properties of cells. Surface receptors involved in activation: mannose receptors bind glycoproteins of bacteria, toll-like receptors, cell communication receptors cytokines and chemokines during infection or tissue injury, cam wbc adhesion, complement receptors that recognize degraded fragments.
